Medication Adherence Seminar Series – Summer 2014
Comparative Effectiveness Research (CER) Strategic Initiative, NC TraCS
This series addresses methods of measuring medication adherence, the advantages and disadvantages of the different methods, and other methodological challenges and study design issues. Researchers with experience in this area will lead each session with approximately a 30 minute overview of the topic area/issues followed by 30 minutes of question/answer and interchange. Prior to each session, PubMed links to one or two articles will be circulated and will be posted on this webpage. These articles will not be critiqued, but will serve as a foundation for the presentation and as a resource following the presentation.
WHEN: Fridays, 9-10 am (sessions will occur about every 3-4 weeks)
WHERE: Brinkhous-Bullitt Building, 2nd Floor (Room #219), 160 N. Medical Drive, UNC
• May 9, 2014:
Self-Report Medication Adherence Measures: Examples in Cardiovascular Disease & Cancer
Leah L Zullig, PhD, MPH; Research Health Science Specialist, Durham Veterans Affairs Medical Center, Health Services Research and Development Center of Innovation; Adjunct Assistant Professor, UNC Gillings School of Global Public Health, Department of Health Policy and Management.
Recommended reading: Zullig LL, Peterson ED, Bosworth HB. Ingredients of successful interventions to improve medication adherence. JAMA. 2013 Dec 25;310(24):2611-2. doi: 10.1001/jama.2013.282818. PubMed PMID: 24264605.
• May 30, 2014:
Medication Adherence Measures and Predictors in the Atherosclerosis Risk In Communities (ARIC) Study
Jo Ellen Rodgers, PharmD; Associate Director, Clinical Fellowship Programs, DPET; Director, PGY2 Residency in Cardiology, UNC Hospitals; Clinical Associate Professor, UNC Eshelman School of Pharmacy, Pharmacotherapy and Experimental Therapeutics
Emily Thudium, PharmD; Postdoctoral Research Associate, United Therapeutics Drug Development Fellow, UNC Eshelman School of Pharmacy, Pharmacotherapy & Experimental Therapeutics
Recommended reading: An J, Nichol MB. Multiple medication adherence and its effect on clinical outcomes among patients with comorbid type 2 diabetes and hypertension. Med Care. 2013 Oct;51(10):879-87. doi: 10.1097/MLR.0b013e31829fa8ed. PubMed PMID: 23929398.
• June 27, 2014:
Medication Adherence in Relation to Discharge Indications and Hospital Readmission: The ARIC study
Sally Clark Stearns, PhD; Professor, UNC Gillings School of Global Public Health, Health Policy and Management;
Carla A. Sueta, PhD, MD; Professor, UNC School of Medicine, Division of Cardiology
Recommended reading: Setoguchi S, Choudhry NK, Levin R, Shrank WH, Winkelmayer WC. Temporal trends in adherence to cardiovascular medications in elderly patients after hospitalization for heart failure. Clin Pharmacol Ther. 2010 Oct;88(4):548-54. doi: 10.1038/clpt.2010.139. Epub 2010 Sep 8. PubMed PMID: 20827266.
• July 18, 2014:
Claims-Based Measures of Medication Adherence and Methodological Issues.
Stacie Dusetzina, PhD; Assistant Professor, UNC School of Medicine, Health Policy and Management
Joel Farley, PhD; Associate Professor, UNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy
1. Hess LM, Raebel MA, Conner DA, Malone DC. Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother. 2006 Jul-Aug;40(7-8):1280-88. PubMed PMID: 16868217.
2. Jonikas MA, Mandl KD. Surveillance of medication use: early identification of poor adherence. J Am Med Inform Assoc. 2012 Jul-Aug;19(4):649-54. doi: 10.1136/amiajnl-2011-000416. Epub 2011 Nov 19. PubMed PMID: 22101969; PubMed Central PMCID: PMC3384104.
• August 22, 2014:
Methodological issues when using medication adherence as an exposure or covariate in CER
Jenny Lund, PhD, MSPH; Assistant Professor, UNC Gillings School of Global Public Health, Epidemiology
Til Stürmer, MD, PhD, MPH; Professor, Director, Center for Pharmacoepidemiology, UNC Gillings School of Global Public Health, Epidemiology
Dormuth CR, Patrick AR, Shrank WH, Wright JM, Glynn RJ, Sutherland J, Brookhart MA. Statin adherence and risk of accidents: a cautionary tale. Circulation. 2009 Apr 21;119(15):2051-7. doi: 10.1161/CIRCULATIONAHA.108.824151. Epub 2009 Apr 6. PubMed PMID: 19349320; PubMed Central PMCID: PMC2744446.
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