The Sheps Center is a collaborative, interdisciplinary environment, with senior research fellows and directors from a wide range of backgrounds. Sheps Center principal investigators have faculty appointments in the UNC School of Medicine (Family Medicine, Medicine, Geriatric Medicine, Hematology/Oncology, Pediatrics, Psychiatry, and Social Medicine), Gillings Global School of Public Health (Health Policy and Management and Maternal and Child Health), UNC School of Social Work, UNC Eshelman School of Pharmacy, and the UNC School of Nursing.

Sheps Center researchers are engaged in cutting edge health services research to help both patients and providers.