Comparative Effectiveness of Management Options for Localized Prostate Cancer

This project will use secondary analysis of existing data, retrospective analysis of SEER/Medicare data and prospective cohort data to comparative the effectiveness of management options for early prostate cancer. 1: To directly compare the disease-free and overall survival in men with localized prostate cancer treated by retropubic prostatectomy, minimally-invasive prostatectomy, 3D conformal radiation therapy, intensity-modulated radiation therapy, proton radiation therapy, and brachytherapy, stratified by prostate cancer risk group, race, and age group. 2: To directly compare the prostate-cancer specific and overall quality of life in men with localized prostate cancer treated by the same treatment modalities, stratified by age group. 3: To directly compare the disease characteristics, disease-free survival and quality of life outcomes in African American men and men living in Federally-designated Medically Underserved Areas. 4: To examine disease, other clinical and demographic factors that affect the decision making process of men with newly-diagnosed prostate cancer. What is the comparative effectiveness of management strategies for localized prostate cancer (e.g., active surveillance, radical prostatectomy [conventional, robotic, and laparoscopic] and radiotherapy [conformal, brachytherapy, proton-beam, and intensity-modulated radiotherapy])?

Principal Investigator: Til Sturmer Task Order PI; Paul Godley Task PI
Funding Source: AHRQ
Total Project Period: 7/15/10- 7/14/13